WHAT'S NEW @ KATZE LAB
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News Interviews: Swine Flu
UW will lead $13 million collaborative vaccine project
Stimulus money to boost study of AIDS, cancer and more
Dr. Katze appears on King 5 News to address questions about Swine Flu
Dr. Katze discusses Swine Flu on KUOW
New systems biology awards enable detailed study of microbes
UW receives nearly $17 million to study emerging respiratory viruses
Rhesus macaque genome may hold clues for human health and evolution
1918 flu ravaged body's defenses
Research on monkeys finds resurrected 1918 flu killed by turning the body on itself
Study uncovers lethal secret of 1918 influenza virus
NIAID Awards Systems biology contract
Dr. Katze is Principal Investigator on a new NIAID contract awarded to the University of Washington. Work performed under the contract will focus on using systems biology approaches to study the virus-host interactions and pathogenesis of two emerging respiratory viral pathogens, highly pathogenic H5N1 avian influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV). Co-investigators include Dr. Yoshihiro Kawaoka (University of Wisconsin), Dr. Ralph Baric (University of North Carolina), Dr. Shannon McWeeney (Oregon Health & Science University), and Drs. Richard Smith, Thomas Metz, and Katrina Waters (Pacific Northwest National Laboratory).
For more information, please visit systemsvirology.org
Publication highlights
Katze et al., Nature Reviews Immunology 8:644-654, 2008
Functional genomics approaches are increasingly being used to study the processes of viral triggering and regulation of host immune responses. This review highlights recent advances in the use of these approaches to unravel some of the complexities of virus-host interactions and provide new insights into how RNA viruses cause disease.
Chan et al., Journal of Virology 81:7571-7583, 2007
Eric Chan et al. report on the first large-scale quantitative analysis of protein abundance changes in a CD4+ T cell line infected with HIV-1. This study quantified over 3,200 proteins and revealed changes in the abundance of proteins associated with nuclear transport, ubiquitination, and cell-cycle progression. In addition, changes in the abundance of cellular proteins known to interact with HIV-1 proteins were identified.